Product Name :
NOX4 Mouse Monoclonal Antibody [G11-H2]
Predicted band size :
Observed band size :
Synonyms:
Kidney oxidase 1 antibody Kidney oxidase-1 antibody Kidney superoxide producing NADPH oxidase antibody Kidney superoxide-producing NADPH oxidase antibody KOX 1 antibody KOX antibody Kox-1 antibody KOX1 antibody NADPH antibody NADPH oxidase 4 antibody 展开
Function :
Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox.tert-Butyl 2-aminoacetate manufacturer Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB.800401-68-7 Chemscene May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation.PMID:33601901 Isoform 3 is not functional. Isoform 5 and isoform 6 display reduced activity.
Antibody Type:
Mouse Monoclonal Antibody
Immunogen :
Purified recombinant fragment of human NOX4 (AA: 210-310) expressed in E. Coli.
Species reactivity:
Human
Verify application:
WB, ICC, IHC-P, FC
Coupling :
unconjugated
Clone number:
G11-H2
RRID:
Form :
Liquid
Concentration :
2ug/ul
Storage instructions:
4℃; -20℃ for long term storage.
Storage buffer solution:
Purified antibody in PBS with 0.05% sodium azide.
Subtype:
IgG1
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
67 kDa
Positive control :
Human NOX4 recombinant protein, NOX4-hIgGFc transfected HEK293 cell lysate, Hela, human cervical cancer tissue, human bladder cancer tissue.