Product Name :
SN38 Recombinant Rabbit Monoclonal Antibody [PSH0-05]
Predicted band size :
Observed band size :
Synonyms:
SN-38 antibody SN38 antibody
Function :
SN-38 is an antineoplastic drug. It is the active metabolite of irinotecan (an analog of camptothecin – a topoisomerase I inhibitor) but has 1000 times more activity than irinotecan itself. In vitro cytotoxicity assays show that the potency of SN-38 relative to irinotecan varies from 2- to 2000-fold. SN38 is formed via hydrolysis of irinotecan by carboxylesterases and metabolized via glucuronidation by UGT1A1. The variant of UGT1A1 in ~10% of Caucasians which leads to poor metabolism of SN-38 predicts irinotecan toxicity, as it is then less easily excreted from the body in its SN-38 glucuronide form. SN-38 and its glucuronide are lost into the bile and intestines. It can cause the symptoms of diarrhoea and myelosuppression experienced by ~25% of the patients administered irinotecan.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
SN38-OVA
Species reactivity:
Species independent
Verify application:
ELISA, WB
Coupling :
unconjugated
Clone number:
PSH0-05
RRID:
AB_3072375
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.Price of 1196154-13-8 Aliquot store at -20℃.1260879-61-5 custom synthesis Avoid repeated freeze / thaw cycles.PMID:33736721
Storage buffer solution:
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
1:10,000
Molecular weight :
Positive control :