Product Name :
Sck Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
Protein Sck antibody SCK antibody SH2 domain protein C2 antibody SHC transforming protein 2 antibody SHCB antibody Src homology 2 domain containing transforming protein C2 antibody
Function :
domain:The PID domain mediates binding to the TrkA receptor. Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons. miscellaneous:PubMed:15057824 has shown that SHC2 is poorly phosphorylated by the Trk receptors, in opposite to PubMed:12006576.Formula of 7-Fluoro-5-methoxy-1H-indole PTM:Phosphorylated on tyrosines by the Trk receptors. Contains 1 PID domain. Contains 1 SH2 domain. subunit:Interacts with the Trk receptors in a phosphotyrosine-dependent manner and MEGF12. Once activated, binds to GRB2. tissue specificity:Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus.30132-23-1 web
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
The antiserum was produced against synthesized peptide derived from human SHC2.PMID:33619058 AA range:261-310
Species reactivity:
Human, Rat
Verify application:
WB
Coupling :
unconjugated
Clone number:
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Subtype:
IgG
Purification method :
Immunogen affinity purified.
ELTSA :
Molecular weight :
59 kDa
Positive control :
Fetal brain,Platelet,