Product Name :
3-Aminobenzamide (CAS 3544-24-9)
Synonym :
3-Carboxamidoaniline; 3-(Aminocarbonyl) Aniline;3-AB
Application :
3-Aminobenzamide is An inhibitor of PARP
CAS:
3544-24-9
Purity:
≥97%
Molecular Weight:
136.15
Formula :
C7H8N2O
Physical state:
Solid
solubility :
Soluble in DMF (~30 mg/ml), DMSO (~30 mg/ml), PBS(pH7.2) (~2 mg/ml), water (25 mg/ml), and ethanol (25 mg/ml).
Shipping Condition :
Store at room temperature
Melting point:
115-116° C (lit.22929-52-8 Synonym )
SMILES:
C1=CC(=CC(=C1)N)C(=O)N
References:
:3-aminobenzamide prevents restraint-evoked immunocompromise. | Neigh, GN., et al. 2005. Brain Behav Immun. 19: 351-6. PMID: 15944075Signal transduction in Coprinus congregatus: evidence for the involvement of G proteins in blue light photomorphogenesis. | Kozak, KR. and Ross, IK. 1991. Biochem Biophys Res Commun. 179: 1225-31. PMID: 19301683-Aminobenzamide–a PARP inhibitor enhances the sensitivity of peripheral blood micronucleus and comet assays in mice. | Shekh, K., et al. 2014. Toxicol Mech Methods. 24: 332-41. PMID: 24568202Effect of 3-aminobenzamide on perforation an experimental colitis model. | Menekse, E., et al. 2014. Turk J Gastroenterol. 25 Suppl 1: 86-91. PMID: 259103753-aminobenzamide, one of poly(ADP-ribose)polymerase-1 inhibitors, rescuesapoptosisin rat models of spinal cord injury. | Meng, X., et al. 2015. Int J Clin Exp Pathol. 8: 12207-15. PMID: 267224053-Aminobenzamide Blocks MAMP-Induced Callose Deposition Independently of Its Poly(ADPribosyl)ation Inhibiting Activity.159857-79-1 supplier | Keppler, BD.PMID:33678074 , et al. 2018. Front Plant Sci. 9: 1907. PMID: 30619442Treatment with 3-Aminobenzamide Negates the Radiofrequency-Induced Adaptive Response in Two Cell Models. | Sannino, A., et al. 2019. Int J Environ Res Public Health. 16: PMID: 31382475Effect of 3-Aminobenzamide on the Ultrastructure of Astrocytes and Microvessels After Focal Cerebral Ischemia in Rats. | Wang, J., et al. 2020. Dose Response. 18: 1559325819901242. PMID: 320300923-Aminobenzamide alleviates elevated DNA damage and DNA methylation in a BTBR T+Itpr3tf/J mouse model of autism by enhancing repair gene expression. | Attia, SM., et al. 2020. Pharmacol Biochem Behav. 199: 173057. PMID: 33069747Intervention of 3-aminobenzamide against Dextran Sulphate Sodium induced colitis in mice: Investigations on molecular mechanisms. | Singla, S. and Jena, G. 2022. Eur J Pharmacol. 920: 174861. PMID: 352197303-aminobenzamide protects against colitis associated diabetes mellitus in male BALB/c mice: Role of PARP-1, NLRP3, SIRT-1, AMPK. | Singla, S., et al. 2023. Biochimie. 211: 96-109. PMID: 369347793-Aminobenzamide is lethal to MMS-damaged human fibroblasts primarily during S phase. | Boorstein, RJ. and Pardee, AB. 1984. J Cell Physiol. 120: 345-53. PMID: 6430922Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells. | Heller, B., et al. 1995. J Biol Chem. 270: 11176-80. PMID: 7744749Possible involvement of poly(ADP-ribosyl) polymerase in triggering stress-induced apoptosis. | Nosseri, C., et al. 1994. Exp Cell Res. 212: 367-73. PMID: 8187831Inhibitors of poly(ADP-ribose) polymerase block nitric oxide-induced apoptosis but not differentiation in human leukemia HL-60 cells. | Kuo, ML., et al. 1996. Biochem Biophys Res Commun. 219: 502-8. PMID: 8605017